About the group
Leading researcher: Prof. Dr. Eng. Dancho Lybenov Danalev, Prof. Dr. Eng. Peter Todorov Todorov
Theme: Peptides and hybride heterocycle-peptide molecules with potential applications in medicine; Preparation and purification of biologically active substances from medicinal and aromatic plants using membrane separation.
The scientific group includes several main areas of research, with specific research intentions for a period of 4 years /2023-2026/:
- Peptidomimetics and bioconjugates with potential application in medicine, especially for treatment of diseases such as cancer, chronic and acute pain, inflammation, bacterial infections:
– design, synthesis and study of biological activity in vitro and in vivo of newly synthesized peptides, their metal complexes with biogenic metals, heterocyclic compounds and hybrid heterocyclic-peptide molecules with anticancer, antimicrobial and some other important pharmacological activities by including unnatural amino acids in their structure in order to improve their pharmacodynamics, search for synergistic effect between the peptide fragment and the additional pharmacophore;
– Investigation of the redox behavior of newly synthesized N-modified hemorphin analogs in different electrolyte environments (pH 1.2–12.8) by applying voltammetric techniques. Investigation of different biological activities of the newly synthesized hemorphine analogues.
– synthesis and investigation of the properties of new amino acid biosurfactants as carriers of biologically active agents.
– research on expanding the possibilities for efficient utilization of waste products in the production of essential oils from aromatic plants and herbs using nanomembrane separation. Development of reverse osmosis and nanofiltration membranes with increased resistance to clogging by biologically active components of medicinal and aromatic plants. Development of a high intensity membrane module with improved performance.
- Preparation and purification of biologically active substances from medicinal and aromatic plants using membrane separation.
Leading researcher: Prof. Dr. Eng. Dancho Lybenov Danalev, Prof. Dr. Eng. Peter Todorov Todorov
Theme: Peptides and hybride heterocycle-peptide molecules with potential applications in medicine; Preparation and purification of biologically active substances from medicinal and aromatic plants using membrane separation.
The scientific group includes several main areas of research, with specific research intentions for a period of 4 years /2023-2026/:
- Peptidomimetics and bioconjugates with potential application in medicine, especially for treatment of diseases such as cancer, chronic and acute pain, inflammation, bacterial infections:
– design, synthesis and study of biological activity in vitro and in vivo of newly synthesized peptides, their metal complexes with biogenic metals, heterocyclic compounds and hybrid heterocyclic-peptide molecules with anticancer, antimicrobial and some other important pharmacological activities by including unnatural amino acids in their structure in order to improve their pharmacodynamics, search for synergistic effect between the peptide fragment and the additional pharmacophore;
– Investigation of the redox behavior of newly synthesized N-modified hemorphin analogs in different electrolyte environments (pH 1.2–12.8) by applying voltammetric techniques. Investigation of different biological activities of the newly synthesized hemorphine analogues.
– synthesis and investigation of the properties of new amino acid biosurfactants as carriers of biologically active agents.
– research on expanding the possibilities for efficient utilization of waste products in the production of essential oils from aromatic plants and herbs using nanomembrane separation. Development of reverse osmosis and nanofiltration membranes with increased resistance to clogging by biologically active components of medicinal and aromatic plants. Development of a high intensity membrane module with improved performance.
- Preparation and purification of biologically active substances from medicinal and aromatic plants using membrane separation.
